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Testosterone Cypionate Injections

Depo-Testosterone testosterone cypionate injection, USP CIII 200 mg mL Vial Novaplus®

Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia. Gynecomastia and excessive frequency and duration of penile erections. Safety and effectiveness in pediatric patients below the age of 12 years have not been established. Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism. A decrease in serum proinsulin and insulin was noted after 3 months (43) or 6 months (45), and a decrease in homeostasis model assessment index of insulin resistance (HOMA-IR) after 3 months (36) or 6 months (45–47). Treatment of hypogonadal men with testosterone is rewarding, for the patients as well as the physician.

Oral testosterone is easy to administer, but it must be taken with food. Although injectable therapy has flexible dosing, there is a risk of symptom fluctuations. Testosterone pellets have a long duration of action; however, they require an in-office procedure.

Tell your health care provider if you have an enlarged prostate or BPH. Testosterone can worsen symptoms of BPH or may increase the risk of prostate cancer. Tell your health care provider if you have any worsening prostate symptoms, such as having a hard time peeing or a weak flow, more frequent peeing, or having an urgent need to pee. Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Testosterone may increase your risk of sleep apnea, which is a condition where breathing stops and starts again while sleeping. You may be at a higher risk of sleep apnea if you have obesity or lung problems, such as asthma or chronic obstructive pulmonary disease (COPD). Tell your health care provider if you or your bed partner notices that you have symptoms such as snoring, sleepiness during the day, restless sleeping, or waking up suddenly after gasping or choking.

Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Additionally, some of these medications are available in low-cost generic formulations. Disadvantages generally include less of a rise in testosterone levels compared to testosterone-containing therapies. Some of these medications are used off-label to increase testosterone. Cylindrical pellets that are about the size of a grain of rice.

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly. The first transdermal patches found to be efficacious were scrotal patches in the 1980s (21).

The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men (28, 29). Upon testosterone administration there is a decrease in fat mass and an increase in lean body mass and the net result is often, but not always, that total body weight does not show major changes. An increase in total mass was found after 3 months (14) and an increase in weight in elderly men after 3 months (30). A decrease in weight has been observed after 3 months (31) and 6 months (17), with further progressive decrease over 24 months (32). An increase in total body mass, lean body mass, and a decrease in fat mass were found after 3 months (14, 30) or 6 months (17). A decrease in fat mass has been widely reported after 3 months (14, 30, 31) or 6 months (17), and a decrease in percent fat mass equally after 3 months (14, 31).

Subdermal testosterone pellet vs injection pellets were the first effective formulation for androgen replacement therapy, developed in the 1940s (20). Testosterone pellets consist of crystalline testosterone and are created through high-temperature molding and designed for consistent and prolonged release (21). Absorption occurs through uniform erosion of the pellet’s surface in correspondence to the solubility of testosterone in extracellular fluid. Dosing varies on patient age and diagnosis, and is adjusted to the patient’s response and manifestation of adverse reactions. General dosing recommendations are 150 to 450 mg implanted subdermally in the hip area or another fatty area at 3 to 6 month intervals (22). Testosterone pellets are available generically in 12.5, 25, 37.5, and 50 mg pellets.

Effects on lipids appear after 4 weeks, maximal after 6–12 months. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3–12 months. Changes in fat mass, lean body mass, and muscle strength occur within 12–16 weeks, stabilize at 6–12 months, but can marginally continue over years. Effects on bone are detectable already after 6 months while continuing at least for 3 years. Advantages include efficacy and patient satisfaction, weekly to biweekly dosing, and low cost. Disadvantages include increased fluctuation (peaks and valleys) in testosterone levels compared to daily dosing options and the requirement for needles and possibly self-injection.

Keep reading to learn more about the different ways to take testosterone replacement therapy through FOLX. Testosterone enanthate injection (Xyosted) comes as a solution (liquid) to be injected subcutaneously (under the skin) once a week by yourself or a caregiver. A program has been set up to limit the use of testosterone undecanoate injection (Aveed) and to inform people about the increased risk of breathing problems and allergic reactions while receiving this medication. The program also makes sure that everyone who received this medication understands the risks and benefits from this medication and receives the medication in a setting where they can be monitored for serious reactions. Just being tired isn’t enough to seek testosterone replacement therapy. General fatigue and malaise has so many other causes, and when most men get a blood test, the result is a normal testosterone level.